![]() ![]() Moreover, in vitro gel shift analysis and chromatin immunoprecipitation indicate that the P-cadherin gene is a direct transcriptional target for PAX3/7–FOXO1A. ![]() Using mouse models carrying modified Pax3 alleles, we demonstrate that P-cadherin is expressed in the dermomyotome and lies genetically downstream from the myogenic factor Pax3. We then show that expression of a PAX3 dominant negative variant inhibits P-cadherin expression in ARMS cells. To this aim, we analyzed transcriptomic data from rhabdomyosarcoma samples and found that P-cadherin expression is correlated with PAX3/7–FOXO1A presence. ![]() Identification of their targets is essential for understanding ARMS pathogenesis. Alveolar rhabdomyosarcoma (ARMS) is an aggressive childhood cancer of striated muscle characterized by the presence of the PAX3–FOXO1A or PAX7–FOXO1A chimeric oncogenic transcription factor. ![]()
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